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Background: |
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
FZD8 |
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Immunogen: |
Synthetic peptide of human FZD8 |
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Full name: |
frizzled family receptor 8 |
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Synonyms： |
FZ-8; hFZ8 |
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SwissProt: |
Q9H461 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human esophagus cancer and Human liver cancer |
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IHC Recommend dilution: |
50-200 |
