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中文名称：AKT1抗原（重组蛋白）
英文名称：AKT1 Antigen (Recombinant Protein)
储 存：冷冻（-20℃）
相关类别：抗原
概述
Fusion protein corresponding to a region derived from 10-224 amino acids of human AKT1
技术规格
Full name:
V-akt murine thymoma viral oncogene homolog 1
Synonyms:
AKT, PKB, RAC, PRKBA, PKB-ALPHA, RAC-ALPHA
Swissprot:
P31749
Gene Accession:
BC000479
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
