兔抗HGF多克隆抗体

Background:

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

Applications:

ELISA, IHC

Name of antibody:

HGF

Immunogen:

Fusion protein of human HGF

Full name:

hepatocyte growth factor (hepapoietin A; scatter factor)

Synonyms：

SF; HGFB; HPTA; F-TCF; DFNB39

SwissProt:

P14210

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and Human gastric cancer

IHC Recommend dilution:

50-200