小鼠抗MSL2单克隆抗体

Background:

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Applications:

WB

Name of antibody:

MSL2

Immunogen:

Fusion protein of human MSL2

Full name:

MSL complex subunit 2

Synonyms:

MSL-2; MSL2L1; RNF184

SwissProt:

Q9HCI7

WB Predicted band size:

63 KD

WB Positive control:

Hela cell lysate

WB Recommended dilution:

500-2000