兔抗ALKBH8多克隆抗体

Background:

ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.

Applications:

ELISA, IHC

Name of antibody:

ALKBH8

Immunogen:

Full length fusion protein

Full name:

alkB homolog 8, tRNA methyltransferase

Synonyms：

ABH8; TRM9; TRMT9

SwissProt:

Q96BT7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer and Human esophagus cancer

IHC Recommend dilution:

20-100