小鼠抗C1R单克隆抗体

Background:

The complement component proteins, C1, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the classical pathways of the serum complement system. C1 consists of a calcium dependent trimolecular complex of C1r, C1s and C1q in a 2:2:1 ratio. C1r is a dimer formed of two identical chains that are activated by cleavage into two chains, A and B.

Applications:

WB

Name of antibody:

C1R

Immunogen:

Fusion protein of human C1R

Full name:

complement component 1, r subcomponent (C1R)

Synonyms:

complement component 1, r subcomponent

SwissProt:

P00736

WB Predicted band size:

80 kDa

WB Positive control:

MDCK cell lysate

WB Recommended dilution:

200-1000