小鼠抗ALOX5单克隆抗体

Background:

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

ALOX5

Immunogen:

Fusion protein of human ALOX5

Full name:

arachidonate 5-lipoxygenase

Synonyms:

5-LO; 5LPG; LOG5; 5-LOX

SwissProt:

P09917

IHC positive control:

Human lymphoma tissue and Human endometrium tissue; Human lung cancer and Human breast tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

78 KD

WB Positive control:

Human lung tissue and Human spleen tissue lysates

WB Recommended dilution:

200-1000