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021-54845833/15800441009
中文名称： 兔抗ACVR1多克隆抗体
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Background: |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
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Applications: |
ELISA, WB |
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Name of antibody: |
ACVR1 |
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Immunogen: |
Synthetic peptide of human ACVR1 |
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Full name: |
activin A receptor type I |
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Synonyms: |
FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2 |
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SwissProt: |
Q04771 |
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ELISA Recommended dilution: |
2000-5000 |
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WB Predicted band size: |
57 kDa |
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WB Positive control: |
NIH/3T3 and HUVEC cell lysates |
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WB Recommended dilution: |
200-1000 |
