兔抗ZIC1/2/3多克隆抗体

Background:

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' By similarity.

Applications:

WB, IHC

Name of antibody:

ZIC1/2/3

Immunogen:

Synthesized peptide derived from internal of human ZIC1/2/3.

Full name:

Zic family member 1/2/3

Synonyms：

ZIC; ZNF201/HPE5/HTX; HTX1; ZNF203; VACTERLX

SwissProt:

Q15915/O95409/O60481

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

48/55/51 kDa

WB Positive control:

Jurkat cells and COLO cells lysates

WB Recommended dilution:

500-3000