兔抗C4A(β chain)多克隆抗体

Background:

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

C4A (β chain)

Immunogen:

Synthetic peptide of human C4A (β chain)

Full name:

complement component 4A (β chain)

Synonyms：

C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2

SwissProt:

P0C0L4

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

75 kDa

WB Positive control:

Human serum

WB Recommended dilution:

200-1000