兔抗BEST1多克隆抗体

Background:

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Applications:

ELISA, WB, IHC

Name of antibody:

BEST1

Immunogen:

Synthetic peptide of human BEST1

Full name:

bestrophin 1

Synonyms:

ARB; BMD; BEST; RP50; VMD2; TU15B

SwissProt:

O76090

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

68 kDa

WB Positive control:

Mouse lung tissue lysate

WB Recommended dilution:

200-1000