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中文名称：兔抗BCR多克隆抗体
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Background: |
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
BCR |
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Immunogen: |
Synthetic peptide of human BCR |
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Full name: |
breakpoint cluster region |
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Synonyms： |
ALL; CML; PHL; BCR1; D22S11; D22S662 |
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SwissProt: |
P11274 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human thyroid cancer and Human liver cancer |
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IHC Recommend dilution: |
25-100 |
