兔抗BCL2L13多克隆抗体

Background:

Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.

Applications:

WB

Name of antibody:

BCL2L13

Immunogen:

Fusion protein of human BCL2L13

Full name:

BCL2-like 13 (apoptosis facilitator)

Synonyms：

BCL2L13; MIL1; Protein Mil1; BCL-RAMBO; Bcl2-L-13

SwissProt:

Q9BXK5

WB Predicted band size:

53 kDa

WB Positive control:

Jurkat cells

WB Recommended dilution:

500-2000