兔抗GNRHR多克隆抗体

Background:

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Applications:

ELISA, WB

Name of antibody:

GNRHR

Immunogen:

Synthetic peptide of human GNRHR

Full name:

gonadotropin-releasing hormone receptor

Synonyms:

HH7, GRHR, LRHR, LHRHR, GNRHR1

SwissProt:

P30968

ELISA Recommended dilution:

1000-5000

WB Predicted band size:

28 kDa

WB Positive control:

231 cells and mouse testis tissue

WB Recommended dilution:

500-2000