兔抗PFKFB4多克隆抗体

Background:

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

PFKFB4

Immunogen:

Synthetic peptide of human PFKFB4

Full name:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

SwissProt:

Q16877

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

54 kDa

WB Positive control:

Human testis tissue lysate

WB Recommended dilution:

200-1000