兔抗OAZ1多克隆抗体

Background:

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). Alternatively spliced transcript variants have also been noted for this gene.

Applications:

IHC

Name of antibody:

OAZ1

Immunogen:

Synthesized peptide derived from N-terminal of human OAZ1.

Full name:

ornithine decarboxylase antizyme 1

Synonyms：

AZI; OAZ

SwissProt:

P54368

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100