兔抗NFKBIE多克隆抗体

Background:

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.

Applications:

ELISA, WB, IHC

Name of antibody:

NFKBIE

Immunogen:

Fusion protein of human NFKBIE

Full name:

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Synonyms：

IKBE

SwissProt:

O00221

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human lymphoma and Human esophagus cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

45 kDa

WB Positive control:

PC3 cells

WB Recommended dilution:

200-1000