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Background: |
Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage. |
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Applications: |
WB |
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Name of antibody: |
FEN1 |
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Immunogen: |
Fusion protein of human FEN1 |
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Full name: |
flap structure-specific endonuclease 1 |
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Synonyms： |
FEN1; FEN-1; MF1; RAD2 |
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SwissProt: |
P39748 |
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WB Predicted band size: |
43 kDa |
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WB Positive control: |
NIH3T3, HeLa, Jurkat and Y79 cells, spleen and testis tissue |
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WB Recommended dilution: |
500-2000 |
