兔抗FEN1多克隆抗体

Background:

Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.

Applications:

WB

Name of antibody:

FEN1

Immunogen:

Fusion protein of human FEN1

Full name:

flap structure-specific endonuclease 1

Synonyms：

FEN1; FEN-1; MF1; RAD2

SwissProt:

P39748

WB Predicted band size:

43 kDa

WB Positive control:

NIH3T3, HeLa, Jurkat and Y79 cells, spleen and testis tissue

WB Recommended dilution:

500-2000