兔抗MRPL40多克隆抗体

Background:

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.

Applications:

ELISA, WB, IHC

Name of antibody:

MRPL40

Immunogen:

Fusion protein of human MRPL40

Full name:

mitochondrial ribosomal protein L40

Synonyms:

URIM; L40mt; NLVCF; MRPL22; MRP-L22; MRP-L40

SwissProt:

Q9NQ50

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human thyroid cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

24 kDa

WB Positive control:

K562, A172, Jurkat, LOVO cell lysates

WB Recommended dilution:

1000-5000