兔抗EIF6多克隆抗体

Background:

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

EIF6

Immunogen:

Fusion protein of human EIF6

Full name:

eukaryotic translation initiation factor 6

Synonyms:

CAB; EIF3A; eIF-6; p27BBP; ITGB4BP; b(2)gcn; p27(BBP)

SwissProt:

P56537

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

27 kDa

WB Positive control:

A375, K562, Hela, HepG2 and 293T cells

WB Recommended dilution:

500-2000