兔抗DYRK1A多克隆抗体

Background:

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Applications:

ELISA, WB, IHC

Name of antibody:

DYRK1A

Immunogen:

Synthetic peptide of human DYRK1A

Full name:

dual specificity tyrosine phosphorylation regulated kinase 1A

Synonyms:

MNB; DYRK; HP86; MNBH; MRD7; DYRK1

SwissProt:

Q13627

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human ovarian cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

85 kDa

WB Positive control:

HEPG2 and 293T cell lysates

WB Recommended dilution:

200-1000