兔抗DENND1B多克隆抗体

Background:

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery.

Applications:

ELISA, WB

Name of antibody:

DENND1B

Immunogen:

Fusion protein of human DENND1B

Full name:

DENN domain containing 1B

Synonyms:

FAM31B; C1ORF18; C1orf218

SwissProt:

Q6P3S1

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

86 kDa

WB Positive control:

Human fetal brain tissue and mouse brain tissue lysates

WB Recommended dilution:

500-2000