NEDD4L抗原（重组蛋白）

Full name:

neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Synonyms:

RSP5; NEDD4-2; NEDD4.2; hNEDD4-2

Swissprot:

Q96PU5

Gene Accession:

BC032597

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.