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中文名称： ELAC2抗原（重组蛋白）
英文名称： ELAC2 Antigen (Recombinant Protein)
别 名： ELC2; HPC2; COXPD17
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from C terminal 231 amino acids of human ELAC2 |
|
Full name: |
elaC ribonuclease Z 2 |
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Synonyms: |
ELC2; HPC2; COXPD17 |
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Swissprot: |
Q9BQ52 |
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Gene Accession: |
BC001939 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
