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021-54845833/15800441009
中文名称： DAB2抗原（重组蛋白）
英文名称： DAB2 Antigen (Recombinant Protein)
别 名： DOC2; DOC-2
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 209-447 amino acids of human DAB2 |
|
Full name: |
DAB adaptor protein 2 |
|
Synonyms: |
DOC2; DOC-2 |
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Swissprot: |
P98082 |
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Gene Accession: |
BC003064 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
