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  • NR0B2抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW16945
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中文名称: NR0B2抗原(重组蛋白)

英文名称: NR0B2 Antigen (Recombinant Protein)

别      名: SHP; SHP1

储      存: 冷冻(-20℃)

相关类别: 抗原

概述

Fusion protein corresponding to a region derived from 57-228 amino acids of human NR0B2

技术规格

Full name:

nuclear receptor subfamily 0 group B member 2

Synonyms:

SHP; SHP1

Swissprot:

Q15466

Gene Accession:

BC030207

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.