SUV39H1抗原（重组蛋白）

Full name:

suppressor of variegation 3-9 homolog 1

Synonyms:

MG44; KMT1A; SUV39H; H3-K9-HMTase 1

Swissprot:

O43463

Gene Accession:

BC006238

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.