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Synthetic peptide corresponding to a region derived from 280-292 amino acids of human integrin-binding sialoprotein |
技术规格
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Full name |
integrin-binding sialoprotein |
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Synonyms |
BSP; BNSP; SP-II; BSP-II |
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Swissprot |
P21815 |
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Gene Accession |
NP_004958 |
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Background |
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. |
