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中文名称：AMACR抗原（重组蛋白）
英文名称：AMACR Antigen (Recombinant Protein)
储 存：冷冻（-20℃）
相关类别：抗原
概述
Fusion protein corresponding to a region derived from 15-175 amino acids of human AMACR
技术规格
Full name:
alpha-methylacyl-CoA racemase
Synonyms:
RM; RACE; CBAS4; AMACRD
Swissprot:
Q9UHK6
Gene Accession:
BC009471
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
