兔抗LAT多克隆抗体

Background:

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, WB

Name of antibody:

LAT

Immunogen:

Synthetic peptide of human LAT

Full name:

linker for activation of T cells

Synonyms:

LAT1; pp36

SwissProt:

O43561

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

28 kDa

WB Positive control:

Human lymph gland tissue lysate

WB Recommended dilution:

200-1000