兔抗JPT1多克隆抗体

Background:

Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).

Applications:

ELISA, IHC

Name of antibody:

JPT1

Immunogen:

Fusion protein of human JPT1

Full name:

Jupiter microtubule associated homolog 1

Synonyms:

HN1; ARM2; HN1A

SwissProt:

Q9UK76

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human cervical cancer

IHC Recommend dilution:

30-150