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  • CCL4抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW9848
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中文名称:CCL4抗原(重组蛋白)

英文名称:
CCL4 Antigen (Recombinant Protein)

储      存:
冷冻(-20℃)

相关类别:抗原

概述

Fusion protein corresponding to a region derived from 24-92 amino acids of human CCL4


技术规格

Full name:

chemokine (C-C motif) ligand 4

Synonyms:

ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta

Swissprot:

P13236

Gene Accession:

BC104226

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.