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中文名称：BRCA1抗原（重组蛋白）
英文名称：BRCA1 Antigen (Recombinant Protein)
储 存：冷冻（-20℃）
相关类别：抗原
概述
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Fusion protein corresponding to C terminal 300 amino acids of human BRCA1 |
技术规格
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Full name: |
breast cancer 1, early onset |
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Synonyms: |
IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53 |
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Swissprot: |
P38398 |
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Gene Accession: |
BC072418 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. |
