小鼠抗MSH2单克隆抗体

Background:

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

MSH2

Immunogen:

Fusion protein of human MSH2

Full name:

mutS homolog 2

Synonyms:

FCC1; COCA1; HNPCC; LCFS2; HNPCC1

SwissProt:

P43246

WB Predicted band size:

105 kDa

WB Positive control:

CEM, Jurkat, 293T, K562 and A431 cell lysates

WB Recommended dilution:

1000-5000