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中文名称： UMPS 抗原（重组蛋白）
英文名称： UMPS Antigen (Recombinant Protein)
别 名： uridine monophosphate synthetase; OPRT
相关类别：抗原
储 存： 冷冻（-20℃）
概 述
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Full name: |
uridine monophosphate synthetase |
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Synonyms: |
OPRT |
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Swissprot: |
P11172 |
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Gene Accession: |
BC000364 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. |
