兔抗ZFAND5多克隆抗体

Background:

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Applications:

ELISA, WB, IHC

Name of antibody:

ZFAND5

Immunogen:

Full length fusion protein

Full name:

zinc finger, AN1-type domain 5

Synonyms：

ZA20D2; ZNF216; ZFAND5A

SwissProt:

O76080

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human lung cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

23 kDa

WB Positive control:

Mouse fat tissue lysate

WB Recommended dilution:

500-2000