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Background: |
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. |
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Applications: |
WB, IHC |
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Name of antibody: |
SRC(Phospho-Tyr418) |
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Immunogen: |
Peptide sequence around phosphorylation site of tyrosine 418(N-E-Y(p)-T-A)derived from Human Src. |
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Full name: |
SRC proto-oncogene, non-receptor tyrosine kinase |
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Synonyms： |
ASV; SRC1; c-SRC; p60-Src |
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SwissProt: |
P12931 |
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IHC positive control: |
Human breast carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
60 kDa |
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WB Positive control: |
COLO205 cells lysates |
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WB Recommended dilution: |
500-1000 |
