兔抗PRKAR2B(Phospho-Ser113)多克隆抗体

Background:

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.

Applications:

WB

Name of antibody:

PRKAR2B(Phospho-Ser113)

Immunogen:

Peptide sequence around phosphorylation site of Serine113(R-R-A(p)-S-V) derived from Human PKA-R2β.

Full name:

protein kinase, cAMP-dependent, regulatory, type II, beta

Synonyms：

PRKAR2; RII-BETA

SwissProt:

P31323

WB Predicted band size:

46 kDa

WB Positive control:

COS7 cells lysates treated with PMA

WB Recommended dilution:

500-1000