兔抗EIF4EBP1(Phospho-Thr37)多克隆抗体

Background:

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Applications:

WB, IHC

Name of antibody:

EIF4EBP1(Phospho-Thr37)

Immunogen:

Synthetic peptide of human EIF4EBP1(Phospho-Thr37)

Full name:

eukaryotic translation initiation factor 4E binding protein 1

Synonyms:

BP-1; 4EBP1; 4E-BP1; PHAS-I

SwissProt:

Q13541

IHC positive control:

Human breast carcinoma tissue;

IHC Recommend dilution:

50-100

WB Predicted band size:

13 kDa

WB Positive control:

MDA-MB-435 cells lysates untreated or EGF-treated (200 ng/ml lysates 30min)

WB Recommended dilution:

500-1000