兔抗DNASE1多克隆抗体

Background:

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Applications:

ELISA, IHC

Name of antibody:

DNASE1

Immunogen:

Fusion protein of human DNASE1

Full name:

deoxyribonuclease I

Synonyms：

DNL1; DRNI

SwissProt:

P24855

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100