购物车
帮助
021-54845833/15800441009
中文名称：ZAP70抗原（重组蛋白）
英文名称： ZAP70 Antigen (Recombinant Protein)
别 名： SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 420-619 amino acids of human ZAP70 |
|
Full name: |
zeta chain of T cell receptor associated protein kinase 70 |
|
Synonyms: |
SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70 |
|
Swissprot: |
P43403 |
|
Gene Accession: |
BC039039 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. |
