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中文名称：POLH 抗原（重组蛋白）
英文名称： POLH Antigen (Recombinant Protein)
别 名： DNA polymerase eta; XPV; XP-V; RAD30; RAD30A
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 215-414 amino acids of human POLH |
技术规格：
|
Full name: |
DNA polymerase eta |
|
Synonyms: |
XPV; XP-V; RAD30; RAD30A |
|
Swissprot: |
Q9Y253 |
|
Gene Accession: |
BC015742 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. |
