购物车
帮助
021-54845833/15800441009
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Full name |
Programmed cell death 1 |
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Synonyms |
PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l |
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Swissprot |
Q15116 |
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Gene Accession |
NP_005009 |
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Background |
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. |
