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中文名称：IL1B抗原（重组蛋白）
英文名称： IL1B Antigen (Recombinant Protein)
别 名： IL-1; IL1F2; IL1-BETA
储 存： 冷冻（-20℃）
相关类别：抗原
概述
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Fusion protein corresponding to a region derived from 1-269 amino acids of human IL1B |
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Full name: |
interleukin 1 beta |
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Synonyms: |
IL-1; IL1F2; IL1-BETA |
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Swissprot: |
P01584 |
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Gene Accession: |
BC008678 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
