RETNLB抗原（重组蛋白）

ull name:

resistin like beta

Synonyms:

XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta

Swissprot:

Q9BQ08

Gene Accession:

BC113502

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Resistin-like beta is a protein that in humans is encoded by the RETNLB gene. An infusion of either resistin or RELMB in rats rapidly induced severe hepatic but not peripheral insulin resistance. Increases in circulating resistin or RELMB levels markedly stimulated hepatic glucose production despite the presence of fixed physiologic insulin levels. This enhanced rate of glucose output was due to increased flux through glucose-6-phosphatase. The results supported the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.