小鼠抗PDGFRA单克隆抗体

Background:

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].

Applications:

WB, IHC

Name of antibody:

PDGFRA

Immunogen:

Fusion protein of human PDGFRA

Full name:

platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)

Synonyms:

CD140A; PDGFR-2; PDGFR2; RHEPDGFRA

SwissProt:

P16234

IHC positive control:

human colon tissue and adenocarcinoma of human colon tissue; human Ovary tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

123 kDa

WB Positive control:

NIH/3T3 cell lysate

WB Recommended dilution:

500-2000