兔抗ZNF131多克隆抗体

Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF131 (Zinc finger protein 131) is a 623 amino acid nuclear protein that contains one BTB (POZ) domain and six C2H2-type zinc fingers. With predominant expression found in brain, it is likely that ZNF131 plays a role as a transcription regulator during development and organogenesis of the adult central nervous system. ZNF131 also represses ER (Estrogen receptor alpha)-mediated transactivation by interrupting ER binding to the estrogen-response element. There are two isoforms of ZNF131 that are produced as a result of alternative splicing events.

Applications:

ELISA, WB, IHC

Name of antibody:

ZNF131

Immunogen:

Fusion protein of human ZNF131

Full name:

zinc finger protein 131

Synonyms:

ZBTB35; pHZ-10

SwissProt:

P52739

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

71 kDa

WB Positive control:

Human testis tissue and Rat brain tissue lysates，Jurkat and Hela cell lysates

WB Recommended dilution:

200-1000