欢迎来到上海通蔚!

021-54845833/15800441009

品质保证 · 通蔚试剂

当前位置: 首页 > 科研产品 > 科研抗体 > 其他抗体 > ERBB2 抗原
  • ERBB2 抗原

    规格:
    数量:

    购买数量

    价格:
    • 品牌 : 通蔚生物
    • 目录号 : TW10718
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
    • 商品库存:75
  • 商品详情
  • 参考文献
  • 说明书下载
  • 商品评论0
  • 相关产品

中文名称: ERBB2 抗原

英文名称: ERBB2 antigen

相关类别: 抗原

储      存: 冷冻(-20℃)

概述

Synthetic peptide corresponding to a region derived from 1240-1255 amino acids of human ERBB2


技术规格

Full name

erb-b2 receptor tyrosine kinase 2

Synonyms

NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

Swissprot

P04626

Gene Accession

NP_004439

Background

The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 (homologous to Tyr416 of pp60c-Src) may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway.