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  • C5AR1抗原(重组蛋白)

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英文名称: C5AR1 Antigen (Recombinant Protein)


别      名: C5A; C5AR; C5R1; CD88

相关类别: 抗原

储      存: 冷冻(-20℃)

概      述

Fusion protein corresponding to a region derived from 151-350 amino acids of human C5AR1

技术规格

Full name:

complement component 5a receptor 1

Synonyms:

C5A; C5AR; C5R1; CD88

Swissprot:

P21730

Gene Accession:

BC008982

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).